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KMID : 1149220110190010233
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Korean Journal of Oriental Medical Prescription
2011 Volume.19 No. 1 p.233 ~ p.241
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Acute Toxicity Study on Ssanghwa-tang Extract Fermented with Paecilomyces Japonica in Mice
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Lee Ji-Hye
Um Young-Ran
Lee Jae-Hoon
Ma Jin-Yeul
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Abstract
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Objectives:This study was carried out to investigate the acute toxicity and safety of Ssanghwa-tang extract fermented with Paecilomyces japonica.
Methods: To evaluate the acute toxity and safety, 0(control group), 1250, 2500 and 5000 mg/kg of Ssanghwa-tang and fermented Ssanghwa-tang extracts were orally administered to 35 male and 35 female ICR mice. After single administration, we observed number of death, general toxicity, changes of body weight, and autopsy.
Results: Compared with the control group, we could not find any toxic alteration in all treated groups (1250, 2500 and 5000 mg/kg).
Conclusions : LD50 of Ssanghwa-tang and fermented Ssanghwa-tang extracts might be over 5000 mg/kg and it is very safe to ICR mice.
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KEYWORD
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Ssanghwa-tang, Fermentation, Acute toxicity, Paecilomyces japonica, LD50
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